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Traditional risk assessment models, such as the American Society of Anesthesiologists (ASA) classification and the Charlson Comorbidity Index (CCI), while valuable, are relatively macroscopic and fail to fully capture the individualized nutritional and inflammatory status of the patient, thus having limited predictive efficacy ( In recent years, a series of blood-based biomarkers reflecting the body's nutritional reserves and systemic inflammation levels have garnered significant attention due to their convenience, low cost, and good reproducibility

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There, citrate is converted to malate before re-entering the mitochondria to fuel the electron transport chain (129)

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